TBX-3400 FOR SOLID TUMORS
Received Orphan Drug Designation from the U.S. FDA for the treatment of malignant melanoma stages IIB to IV.
Completed a first-in-human safety study in patients with advanced solid tumors. Results showed no severe adverse events, was well tolerated and has been approved by the Japanese Ministry of Health, Labor and Welfare.
Taiga’s TBX-3400 is currently being tested in human clinical trials as a treatment for various solid tumors. Due to the agnostic nature of TBX-3400, a variety of solid tumors are being tested.
We have two active clinical trials evaluating TBX-3400 against solid tumors and plan to initiate two additional trials by the end of the year.
TBX-3400 FOR INFECTIOUS DISEASE
Taiga’s TBX-3400 is currently being tested in a pilot study as a treatment for chronic hepatitis B virus (HBV) associated hepatocellular carcinoma in Thailand. The study is currently recruiting patients and is measuring both tumor markers as well as hepatitis B viremia.
Many infectious diseases can further develop into cancer, particularly hepatitis B’s progression to hepatocellular carcinoma and HPV’s association with head and neck cancer. Taiga’s goal is to provide treatment for the infectious disease prior to disease progression.
TBX-2400 FOR BONE MARROW TRANSPLANTS
Received Orphan Drug Designation from the U.S. FDA and the European Medicines Agency.
Received Advanced Therapy Medicinal Product from the European Medicines Agency.
Granted Rare Pediatric Disease Designation by the U.S. FDA.
Taiga will be launching its first clinical trial for TBX-2400 in the second half of 2021 in adult patients with either myelofibrosis or acute myeloid leukemia. A clinical trial for pediatric patients is projected to begin in the next twelve months.
RED BLOOD CELLS
We have developed a process to treat donated blood products with our protein that enables the blood products to maintain stability while stored at 37°C for an extended period of time, removing the need for cold storage.
Possible areas where this technology may be used:
National Defense applications
Natural Disaster applications
Storage of rare blood types
In addition, we have developed a method to produce an almost unlimited supply of red blood cells in the laboratory. Preclinical studies have shown that these red blood cells maintain function similar to naturally produced red blood cells.
HEMATOPOIETIC STEM CELLS
We are developing methods to expand hematopoietic stem cells ex vivo for use in stem cell transplantation and drug screening.
This technology is in preclinical development, yet has shown promise of accelerating the expansion of stem cells.